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Cocaethylene And Your Body

Concurrent abuse of cocaine and alcohol produces cocaethylene, an active metabolite that is can only be formed when ethanol and cocaine coexist in your blood. An association has been seen among humans who ingest cocaine and ethanol together with enhanced euphoria. That quality is wildly subjective however. There have also been links observed with increased heart rate and an elevated plasma cocaine concentration.

A double-blind placebo/controlled study sought to document behavioral and physiological effects of intranasal cocaethylene administration with cocaine used as a comparator. Cocaethylene ingestion fielded reports of a euphoria akin to that of cocaine. An interesting trend was observed that saw these reported effects significantly vary over time. The subjects were not capable of distinguishing between equal doses of cocaine and cocaethylene despite taking longer to eliminate from the body than cocaine.

Cocaethylene is desired by some that consider it a recreational drug by itself due to reported stimulant, euphoriant, sympathomimetic, anorectic and even local anesthetic properties. It is easy to forget that the desired effects are all a result of some other process. At the absolute core it is a transaction, you purchase euphoria, but something had to pay for it.

The asking price offered by cocaethylene is harshly steep. In the brain it relies heavily upon the neurotransmitters serotonin, dopamine and norepinephrine.

Cocaethylene increases the levels of neurotransmission of aforementioned neurotransmitters. It achieves this by interfering with the mechanisms of serotonin, norepinephrine and dopamine transporters. By denying the neurotransmitters anywhere else to go their quantity increases more than normal. This makes cocaethylene a SNDRI (serotonin-norepinephrine-dopamine re-uptake inhibitor). Or a "triple re-uptake inhibitor".

This neuro-tampering is one of the prices cocaethylene demands for "recreation". Most people reported the euphoria to be longer-lasting than cocaine euphoria; just one more price demanded. The trade off is cocaethylene's plasma half-life is three to five times that of cocaine's. Just one more aspect that can seem attractive to a substance abuser.

Even though cocaine and cocaehtylene act on the same neurological receptors they have varying affinities for different neurological receptors. In essence, the two substances act on the same receptors at different levels of efficiency, both being SNDRI's. Cocaine is an extremely efficient blocker of dopamine and norepinephrine transporters in particular. This impedes dopamine re-uptake and sends dopamine levels skyrocketing by up to 150%. And when compared to its metabolite cocaine has been shown to be superior in the ability to bind to the serotonin and norepinephrine transporters.

Cocaethylene appears to often produce a stronger and longer euphoric duration of action than cocaine. The culprit for the difference in the "high" is found with cocaethylene superior potency when it comes to binding up the dopamine transporters. It also happens to be less potent in binding with the serotnin and norepinephrine transporters. The two chemicals almost work inversely.
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